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Parkinson Disease Protein Antigen | PARK Protein | ProSpec
Parkinson's Disease Protein (Park) is a protein located in the mitochondria. It is associated with oxidative stress, leading to Parkinson's disease and other neurodegenerative disorders such as Alzheimer's and Huntington's diseases. Parkinson Disease Protein Interactions.
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PARK7 gene: MedlinePlus Genetics
Normal Function. Collapse Section. The PARK7 gene provides instructions for making the DJ-1 protein. This protein is found in many tissues and organs, including the brain. Studies indicate that the DJ-1 protein has several functions, although none are fully understood. One of the protein's functions may be to help protect cells, particularly brain cells, from oxidative stress.
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PRKN gene: MedlinePlus Genetics
The PRKN gene, one of the largest human genes, provides instructions for making a protein called parkin. Parkin plays a role in the cell machinery that breaks down (degrades) unneeded proteins by tagging damaged and excess proteins with molecules called ubiquitin. Ubiquitin serves as a signal to move unneeded proteins into specialized cell structures known as proteasomes, where the proteins …
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PARK7 - Wikipedia
The gene PARK7, also known as DJ-1, encodes a protein of the peptidase C56 family. The human gene PARK7 has 8 Exons and locates at chromosome band 1p36.23. The human protein deglycase DJ-1 is 20 kDa in size and composed of 189 amino acids with seven β-strands and nine α-helices in total and is present as a dimer. It belongs to the peptidase C56 family of proteins.
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Parkin (ligase) - Wikipedia
Parkin is a protein which in humans is encoded by the PARK2 gene. The precise function of this protein is unknown; however, the protein is a component of a multiprotein E3 ubiquitin ligase complex which in turn is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation.
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Pink1 and Parkin Regulate Drosophila Intestinal Stem Cell
park protein, Drosophila Grant support P41 GM103412/GM/NIGMS NIH HHS/United States R21 AG052732/AG/NIA NIH HHS/United States ...
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Parkin overexpression during aging reduces proteotoxicity
Aberrant protein aggregation and mitochondrial dysfunction have each been linked to aging and a number of age-onset neurodegenerative disorders, including Parkinson disease. Loss-of-function mutations in parkin, an E3 ubiquitin ligase that functions to promote the ubiquitin-proteasome system of prot …
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What kind of protein is the PARK7 gene?
Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene.
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What is the function of Parkin in the cell?
Parkin plays a role in the cell machinery that breaks down (degrades) unneeded proteins by tagging damaged and excess proteins with molecules called ubiquitin. Ubiquitin serves as a signal to move unneeded proteins into specialized cell structures known as proteasomes, where the proteins are degraded.
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How is Parkin related to the Ubiquitin Proteasome System?
Because of its activity in the ubiquitin-proteasome system, parkin belongs to a group of proteins called E3 ubiquitin ligases. Parkin appears to be involved in the maintenance of mitochondria, the energy-producing centers in cells.
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Is there parking in front of protein lab?
There's always plenty of parking whenever I've gone. There were a few people standing near one of the doors to the business, which has been converted into a Pick-up window, with the other acting as the Order window.
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